If you are driving, the most direct route to Gretna Green is via the M6 motorway. From Glasgow, take the M77 then join the M74 before taking the A74(M) towards Gretna Green. From Edinburgh, take the A74(M) southbound towards Carlisle/Gretna Green.
If you are traveling by rail, Gretna Green has its own railway station with direct services available from Glasgow and Carlisle. If you are coming from Edinburgh, you will need to change trains in Carlisle.
If you are traveling from other local landmarks, such as the Lake District or Hadrian's Wall, the most convenient way to get to Gretna Green is via the A74(M) motorway. Alternatively, you can take the train from nearby stations such as Penrith or Hexham.